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AC-099 hydrochloride
CAS No. 849335-07-5
AC-099 hydrochloride ( —— )
产品货号. M37320 CAS No. 849335-07-5
AC-099 hydrochloride (化合物 3) 是一种选择性的 NPFF2R 完全激动剂 (EC50=1189 nM)，也是 NPFF1R 部分激动剂 (EC50=2370 nM)。AC-099 hydrochloride 能减弱脊神经结扎诱导的大鼠超敏性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥323 | 有现货 |
|
| 10MG | ￥517 | 有现货 |
|
| 25MG | ￥751 | 有现货 |
|
| 50MG | ￥1009 | 有现货 |
|
| 100MG | ￥1591 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AC-099 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AC-099 hydrochloride (化合物 3) 是一种选择性的 NPFF2R 完全激动剂 (EC50=1189 nM)，也是 NPFF1R 部分激动剂 (EC50=2370 nM)。AC-099 hydrochloride 能减弱脊神经结扎诱导的大鼠超敏性。
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产品描述AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats.
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体外实验——
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体内实验Animal Model:Male Sprague-Dawley rats (175-300g; spinal nerve ligation (SNL) model).Dosage:30 mg/kg Administration:Intraperitoneal injection; single.Result:Completely attenuated SNL-induced hypersensitivity.
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同义词——
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通路GPCR/G Protein
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靶点Neuropeptide Y Receptor
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受体Neuropeptide Y Receptor
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研究领域——
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适应症——
化学信息
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CAS Number849335-07-5
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分子量301.1
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分子式C9H9Cl2F3N4
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.FC(F)(F)C1=CC(C=NNC(=N)N)=CC=C1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Neuropeptide S (Mous...
Potent endogenous neuropeptide S receptor (NPSR) agonist (EC50 = 3 nM). Induces mobilization of intracellular Ca2+. Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.
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M40
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
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Neuropeptide S (Rat)
Potent endogenous neuropeptide S receptor (NSPR) agonist (EC50 = 3.2 nM). Increases locomotor activity and wakefulness in mice. Also reduces anxiety-like behavior in mice.
